We have only used Webflow for generic landing pages, creating more complex UIs seems to be pretty cumbersome to work with...

I am a big fan of Sketch + Zeplin combination where designers can design in a proper desktop tool and devs get implementation ready mockups, inspector and downloadable assets.

As many of us described below it really depends on your personal preference, on the physical tools and softwares you use on a regular basis.

I had used MM for 4 years mostly for UI design. I never had a problem with it until I had to create some complex illustrations, and the pain in my neck was unbearable after a few days. The pain went away after switching to the MacBook's touch pad -- which can be pretty good, if you are not using multiple screens and have drawings/sketchbook in front of you all the time. :) I knew that I need a mouse.

Although I was afraid of the gamer look, since I switched to MX Master 2S I have no pain and it works like a charm, I don't even think about it -- compared to MM where I always had the feeling that I need to move a teeny-tiny product that does not fit in my palm.

The only thing I REALLY miss is the smooth horizontal scroll which is pretty lame on MX Master.