I use a Wacom Intuos5 M everyday, for everything.

I haven't used a mouse for months, my wrist is hurting me every time i use a mouse.

I work on paper (real not fiftythree) all the time and for a while I had access to a Wacom Cintiq 12". I enjoyed being able to sketch out IA and UX nice and quick and then also quickly edit my sketches, which I can't do with paper and pen quite as easily.

I could take it or leave it at the end of the day. Maybe I would get more out of it with a bigger screen one where I could see more of my work at once.

Yes. I've been using one since 2008, and never looked back. I don't use/need a mouse or trackpad. My wrist thanks me everyday for that, and the red spot in the skin I used to have from using the mouse is now long gone. I suck at drawing, so I use it for interface design, photoshop retouching (I love using brushes and clone stamp with the wacom) and even coding. Flash is the only thing I find harder, because timeframes rectangles are really hard to click, but I hardly ever use flash (thank god for that).

To make it easier for web browsing and any kind of scroll-related task, I use smart scroll http://www.marcmoini.com/sx_en.html which gives me the ability to scroll with the wacom pen while pressing one of the keys in the pen. With coasting it's extremely easy to navigate folders/websites/photoshop layers/any kind of big list, since I don't have a scroll or double finger scroll. I have an intuos now, but a smaller bamboo would suffice, I don't use more than a small portion of it anyway.

I use Wacom Pro L.

I don't use a mouse or the trackpad.

A pen feels more intuitive to me. I do a lot of layouts and minor retouching.

I use a simple, and cheap, Wacom Bamboo, for all my design works: icon creation, UI design... It's way faster than using a mouse or trackpad, and it's also ergonomicaly better, as the movements are wider you don't depend only on the wrist (trackpad cn be bad for your wrist, as you do a lot of rotations, always at the same pivot point)

Have one lying around, gathering dust or supporting the uneven table leg. Tried using it multiple times and not once I felt like it's an improvement over a mouse or trackpad. It makes you look cool though.

I've owned a wacom for years and only ever use it when I need to do high fidelity illustration which is less frequent than once in a blue moon. Personally I'd just use FiftyThree's Paper + iPad for sketching digitally.