I haven't used Origami/Quartz yet, but I intend to. I like the idea of working with SVGs so you get a more pixel accurate representation of what you're building. Plus it seems like it has more fine grained interaction ability.

I have used Framer.js, I was intrigued so I gave it a shot a few weeks ago.

Took me about 2 hours to create this prototype, including: The visual design(sketch), Learning basic Framer.js(w/sketch output), and building the prototype itself. http://e.richietaylor.com/ProjectsAccounting/ Interaction is: Click Construction Project 2B > Building Materials Detail > Lumber Detail

And the back 'Last Breadcrumb' on each page.

We're in an interesting time for UX & Prototyping. A lot of tools surfacing, a lot of tools on the way (EvolveUI, Macaw.io) etc. I'm having a hard time settling on a toolkit.