I dove into some of the Origami files and was able to knock out some nice mobile prototypes in an afternoon. Not bad for first time use. The big downside to me is that I can't actually run it on the phone. Canvas and Storyboard in XCode are another good alternative for a little more power, but also a little more tedious. These are all just tools and some are better in certain situations than others. Knowing the pro's and con's of each is your best bet.