Although it depends on Project, teams etc. But what I have felt that Designing in browser works well when the same person is doing is design and development. luckily I'm doing both at current so it's fine. I jump from Wireframes to Bootstrap. And I do prototyping in tools like Codepen and Jsbin, they have in-built livereload. Every-time I think i have reached at good stage. I save current milestone and start working on new fork of it. I share jsbin url within team, everyone see it on browser and it's responsive. I use http://lorempixel.com to add placeholder images to my prototypes. Subtle patterns bookmarklets to try backgrounds in design http://bradjasper.com/subtle-patterns-bookmarklet/ and css time saves like this http://enjoycss.com
Although it depends on Project, teams etc. But what I have felt that Designing in browser works well when the same person is doing is design and development. luckily I'm doing both at current so it's fine. I jump from Wireframes to Bootstrap. And I do prototyping in tools like Codepen and Jsbin, they have in-built livereload. Every-time I think i have reached at good stage. I save current milestone and start working on new fork of it. I share jsbin url within team, everyone see it on browser and it's responsive. I use http://lorempixel.com to add placeholder images to my prototypes. Subtle patterns bookmarklets to try backgrounds in design http://bradjasper.com/subtle-patterns-bookmarklet/ and css time saves like this http://enjoycss.com